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Despite the fact that sedation plays a central role in intensive care medicine, there are important aspects which have not yet been fully studied.

One key area for investigation are the effects of early depth of sedation and the related short and long term outcome.

Examples of typical antipsychotics include: Atypical, or second generation, antipsychotics are less prone to inducing sedation although some atypical antipsychotic drugs are still associated with extreme tiredness and may shift sleep patterns.

Tolerance to the sedating affect of these drugs may develop during treatment and withdrawal may result in insomnia.

How sedating an antipsychotic is depends on dose and type.

Because of these additive effects, these medications taken with other sedatives or alcohol (also a sedative hypnotic drug) may increase chances for accidental death.

In general, most of the medications that induce sedation may alter breathing and cardiac stability.

The study noted in the article "Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study" aimed to evaluate the current sedative practice and the prevalence of early deep sedation in mechanically ventilated patients as well as the relationship with clinical outcome parameters.

This multicentre prospective longitudinal non-interventional study that was conducted in 11 Malaysian hospitals between March and June 2011. purposed to replicate the findings in the ANZ SPIZE study.

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